Publications
Petroulia S, Hockemeyer K, Tiwari S, Berico P, Shamloo S, Banijamali SE, Vega-Saenz de Miera E, Gong Y, Thandapani P, Wang E, Schulz M, Tsirigos A, Osman I, Aifantis I, Imig J. CRISPR-inhibition screen for lncRNAs linked to melanoma growth and metastasis. bioRxiv [Preprint]. 2024 Jul 24:2024.07.24.604899. doi: 10.1101/2024.07.24.604899. PMID: 39211068; PMCID: PMC11361079.
Garcia MB, Thandapani P. Nutritional intervention as adjuvant therapy for T-cell acute lymphoblastic leukemia. Blood Adv. 2024 Oct 22;8(20):5266-5267. doi: 10.1182/bloodadvances.2024013607. PMID: 39093954; PMCID: PMC11492464.
El-Hachem N, Leclercq M, Susaeta Ruiz M, Vanleyssem R, Shostak K, Körner PR, Capron C, Martin-Morales L, Roncarati P, Lavergne A, Blomme A, Turchetto S, Goffin E, Thandapani P, Tarassov I, Nguyen L, Pirotte B, Chariot A, Marine JC, Herfs M, Rapino F, Agami R, Close P. Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma. Nat Cell Biol. 2024 Jul;26(7):1154-1164. doi: 10.1038/s41556-024-01439-2. Epub 2024 Jun 7. PMID: 38849541; PMCID: PMC11252002.
Tan J, Shenker-Tauris N, Rodriguez-Hernaez J, Wang E, Sakellaropoulos T, Boccalatte F, Thandapani P, Skok J, Aifantis I, Fenyö D, Xia B, Tsirigos A. Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening. Nat Biotechnol. 2023 Aug;41(8):1140-1150. doi: 10.1038/s41587-022-01612-8. Epub 2023 Jan 9. PMID: 36624151; PMCID: PMC10329734.
Witkowski MT, Lee S, Wang E, Lee AK, Talbot A, Ma C, Tsopoulidis N, Brumbaugh J, Zhao Y, Roberts KG, Hogg SJ, Nomikou S, Ghebrechristos YE, Thandapani P, Mullighan CG, Hochedlinger K, Chen W, Abdel-Wahab O, Eyquem J, Aifantis I. NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Nat Immunol. 2022 Oct;23(10):1424-1432. doi: 10.1038/s41590-022-01314-y. Epub 2022 Sep 22. PMID: 36138187; PMCID: PMC9611506.
Lee AK, Aifantis I#, Thandapani P#. Emerging roles for tRNAs in hematopoiesis and hematological malignancies. Trends Immunol. 2022 Jun;43(6):466-477. doi: 10.1016/j.it.2022.03.009. Epub 2022 Apr 27. PMID: 35490133. (# corresponding author)
Thandapani P#, Kloetgen A, Witkowski MT, Glytsou C, Lee AK, Wang E, Wang J, LeBoeuf SE, Avrampou K, Papagiannakopoulos T, Tsirigos A, Aifantis I. Valine tRNA levels and availability regulate complex I assembly in leukaemia. Nature. 2022 Jan;601(7893):428-433. doi: 10.1038/s41586-021-04244-1. Epub 2021 Dec 22. PMID: 34937946; PMCID: PMC9116157. (# corresponding author)
Wang E, Zhou H, Nadorp B, Cayanan G, Chen X, Yeaton AH, Nomikou S, Witkowski MT, Narang S, Kloetgen A, Thandapani P, Ravn-Boess N, Tsirigos A, Aifantis I. Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation. Cell Stem Cell. 2021 Apr 1;28(4):718-731.e6. doi: 10.1016/j.stem.2020.12.005. Epub 2021 Jan 14. PMID: 33450187; PMCID: PMC8145876.
Kloetgen A*, Thandapani P*, Ntziachristos P*, Ghebrechristos Y, Nomikou S, Lazaris C, Chen X, Hu H, Bakogianni S, Wang J, Fu Y, Boccalatte F, Zhong H, Paietta E, Trimarchi T, Zhu Y, Van Vlierberghe P, Inghirami GG, Lionnet T, Aifantis I, Tsirigos A. Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia. Nat Genet. 2020 Apr;52(4):388-400. doi: 10.1038/s41588-020-0602-9. Epub 2020 Mar 23. PMID: 32203470; PMCID: PMC7138649. (* co- first author)
Kloetgen A*, Thandapani P*, Tsirigos A, Aifantis I. 3D Chromosomal Landscapes in Hematopoiesis and Immunity. Trends Immunol. 2019 Sep;40(9):809-824. doi: 10.1016/j.it.2019.07.003. Epub 2019 Aug 15. PMID: 31422902; PMCID: PMC6718347. (* co- first author)
Thandapani P. Super-enhancers in cancer. Pharmacol Ther. 2019 Jul;199:129-138. doi: 10.1016/j.pharmthera.2019.02.014. Epub 2019 Mar 16. PMID: 30885876.
Thandapani P, Aifantis I. Apoptosis, Up the Ante. Cancer Cell. 2017 Oct 9;32(4):402-403. doi: 10.1016/j.ccell.2017.09.009. PMID: 29017053.
Thandapani P, Aranda-Orgilles B, Aifantis I. RNA-binding proteins, the guardians of the marginal zone. Nat Immunol. 2017 May 18;18(6):595-597. doi: 10.1038/ni.3752. PMID: 28518167.
Thandapani P*, Couturier AM*, Yu Z, Li X, Couture JF, Li S, Masson JY, Richard S. Lysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress. Oncotarget. 2017 May 22;8(39):64918-64931. doi: 10.18632/oncotarget.18070. PMID: 29029401; PMCID: PMC5630301. (* co- first author)
Thandapani P*, Song J*, Gandin V, Cai Y, Rouleau SG, Garant JM, Boisvert FM, Yu Z, Perreault JP, Topisirovic I, Richard S. Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes. Elife. 2015 Aug 12;4:e06234. doi: 10.7554/eLife.06234. PMID: 26267306; PMCID: PMC4561382. (* co- first author)
Thandapani P, O'Connor TR, Bailey TL, Richard S. Defining the RGG/RG motif. Mol Cell. 2013 Jun 6;50(5):613-23. doi: 10.1016/j.molcel.2013.05.021. PMID: 23746349.